Publications
List of Published Articles Resulting from the COPDGene Project
1. Washko GR, Dransfield MT, Estepar RS, Diaz A, Matsuoka S, Yamashiro T, Hatabu H, Silverman EK, Bailey WC, Reilly JJ. Airway wall attenuation: A biomarker of airway disease in subjects with COPD. Journal of Applied Physiology 2009; 107:185-191. PMID: 19407254; PMCID: PMC2711787.
http://jap.physiology.org/content/107/1/185.full
http://jap.physiology.org/content/107/1/185.abstract
2. Washko GR, Lynch DA, Matsuoka S, Ross JC, Umeoka S, Diaz A, Sciurba FC, Hunninghake GM, San José Estépar R, Silverman EK, Rosas IO, Hatabu H. Identification of early interstitial lung disease in smokers from the COPDGene study. Academic Radiology 2010; 17:48-53. PMID: 19781963; PMCID: PMC2790552.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790552/pdf/nihms149243.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790552/?report=abstract
3. Regan EA, Hokanson JE, Murphy JR, Make BJ, Lynch D, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD. Genetic epidemiology of COPD (COPDGene) study design. COPD 2010; 7:32-43. PMCID: PMC2924193.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924193/pdf/nihms226362.pdf.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924193/?report=abstract.
4. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nature Genetics 2010: 42:200-202. PMID: 20173748; PMCID: PMC2828499.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828499/pdf/nihms172757.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828499/?report=abstract.
5. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Kong XQ, Anderson WH, Tal-Singer RM, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make B, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology 2011; 45:304-310. PMID: 21037115.
http://ajrcmb.atsjournals.org/content/45/2/304.full.pdf+html.
http://ajrcmb.atsjournals.org/content/45/2/304.abstract.
6. Diaz A, Valim C, Yamashiro T, Estepar RS, Ross JC, Matsuoka S, Bartholmai B, Hatabu H, Silverman E, Washko G. Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers. Chest 2010; 138:880-887. PMID: 20558554; PMCID: PMC2951760.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951760/pdf/100542.pdf.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951760/?report=abstract.
7. Ross JC, Estepar RS, Kindlmann G, Diaz A, Westin CF, Silverman E, Washko G. Automatic lung lobe segmentation using particles, thin plate splines, and maximum a posteriori estimation. Med Image Comput Assist Interv, 2010; 13(Pt3):163-171. PMID: 20879396; PMCID: PMC3049444.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049444/pdf/nihms268290.pdf.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049444/?report=abstract.
8. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, San Jose Estepar R, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO and the COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. New England Journal of Medicine 2011; 364(10):897-906. PMID: 21388308; PMCID: PMC3074462.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074462/pdf/nihms280871.pdf.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074462/?report=abstract.
9. Budoff MJ, Nasir K, Kinney GL, Hokanson JE, Barr RG, Steiner R, Nath H, Lopez-Garcia C, Black-Shinn J, Casaburi R. Coronary artery and thoracic calcium on noncontrast thoracic CT scans: Comparison of ungated and gated examinations in patients from the COPDGene cohort. Journal of Cardiovascular Computed Tomography. 2011; 5:113-118; PMID: 21167806; PMCID: PMC3075464.
http://www.ncbi.nlm.nih.gov/pubmed?term=pmc3075464#.
10. Kim DK, Hersh DP, Washko GR, Hokanson JE, Lynch DA , Newell JD, Murphy JR, Crapo JD, Silverman EK and the COPDGene Investigators. Epidemiology, radiology, and genetics of nicotine dependence. Respiratory Research 2011; 12:9. PMID: 21232152; PMCID: PMC3033825.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033825/pdf/1465-9921-12-9.pdf.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033825/?report=abstract.
11. Hersh CP, Hokanson JE, Lynch DA, Washko GR, Make BJ, Crapo JD, Silverman EK and the COPDGene Investigators. Family history is a risk factor for COPD. Chest 2011; 140:343-350. PMID: 21310839.
http://chestjournal.chestpubs.org/content/140/2/343.full.
http://chestjournal.chestpubs.org/content/140/2/343.abstract.
12. Lipman PJ, Cho M, Bakke P, Gulsvik A, Kong X, Lomas D, Anderson W, Silverman E, Lange C. On the follow-up of genome-wide association studies: an overall test for the most promising SNP's. Genetic Epidemiology 2011; 35:303-309. PMID: 21374717. 2011
http://onlinelibrary.wiley.com/doi/10.1002/gepi.20578/abstract.
13. Yip W-K, Lange C. Quantitative trait prediction based on genetic marker-array data: A simulation study. Bioinformatics 2011; 27(6):745-748; PMID: 21285022; PMCID: PMC3105484.
http://bioinformatics.oxfordjournals.org/content/27/6/745.abstract.
14. Kim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP, and the COPDGene Investigators. Clinical and radiographic correlates of resting hypoxemia and oxygen therapy in the COPDGene Study. Respiratory Medicine 2011; 105(8): 1211-1221; PMID: 21396809, PMCID: PMC3116986.
http://www.ncbi.nlm.nih.gov/pubmed?term=pmc3116986#.
15. Risholm P, Ross J, Washko G, Wells W. Probabilistic elastography: estimating lung elasticity. Information Processing In Medical Imaging. Inf Process Med Imaging 2011; 22:669-710; PMID: 21761697. PMCID: PMC3249413
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249413/pdf/nihms335358.pdf.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249413/?report=abstract.
16. Kim V, Han M, Vance G, Make B, Newell J, Hokanson J, Hersh C, Stinson D, Silverman E, Criner G. The chronic bronchitic phenotype of chronic obstructive pulmonary disease: an analysis of the COPDGene study. Chest 2011; 140:626-633; PMID: 21474571; PMCID: PMC3168856.
http://chestjournal.chestpubs.org/content/140/3/626.full.pdf+html.
http://chestjournal.chestpubs.org/content/140/3/626.abstract.
17. Han M, Everett D, Dransfield M, Criner G, Zhang L, Murphy J, Hansel N, Demeo D, Hanania N, Regan L, Make B, Martinez F, Westney G, Foreman M. Racial differences in quality of life in COPD. Chest 2011; 140:1169-1176. PMID: 21636665.
http://chestjournal.chestpubs.org/content/140/5/1169.full.pdf+html.
http://chestjournal.chestpubs.org/content/140/5/1169.abstract.
18. Wan E, Hokanson J, Murphy J, Regan E, Make B, Lynch D, Crapo J, Silverman E and the COPDGene Investigators. Clinical and radiographic predictors of GOLD-unclassified smokers in COPDGene. Am J Respir Crit Care Med 2011; 184:57-63; PMID: 21493737; PMCID: PMC3172890.
http://ajrccm.atsjournals.org/content/184/1/57.full.pdf+html
http://ajrccm.atsjournals.org/content/184/1/57.abstract
19. Foreman MG, Zhang L, Murphy J, Hansel N, Make B, Hokanson JE, Washko G, Regan E, Crapo JD, Silverman EK, DeMeo DL and the COPDGene Investigators. Early-Onset COPD is associated with female sex, maternal factors, and african american race in the COPDGene study. Am J Respir Crit Care Med 2011; 184:414-420. PMID: 21562134; PMCID: PMC3175544.
http://ajrccm.atsjournals.org/content/184/4/414.full.pdf+html.
http://ajrccm.atsjournals.org/content/184/4/414.abstract.
20. Regan E, Mazur W, Meoni E, ToljamoT, Millar J, Vuopala K, Bowler R, Rahman I, Nicks M, Crapo J, Kinnula V. Smoking and COPD increase sputum levels of extracellular superoxide dismutase. Free Radic Biol Med 2011; 51:726-732. PMID: 21621610.
http://www.sciencedirect.com/science/article/pii/S0891584911003108.
http://www.ncbi.nlm.nih.gov/pubmed?term=21621610#.
21. Kim YI, Schroeder J, Lynch D, Newell J, Make B, Friedlander A, San Jose Estepar R, Hanania N, Washko G, Murphy J, Wilson C, Hokanson J, Zach J, Butterfield K, Bowler R and the COPDGene Investigators. Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD 2011; 8:285-292. PMID: 21756032.
http://informahealthcare.com/doi/pdfplus/10.3109/15412555.2011.586658.
http://www.ncbi.nlm.nih.gov/pubmed?term=21756032#.
22. Han M, Kazerooni E, Lynch D, Liu L, Murray S, Curtis J, Criner G, Kim V, Bowler R, Hanania N, Anzueto A, Make B, Hokanson J, Crapo J, Silverman E, Martinez F, Washko G and the COPDGene Investigators. Chronic obstructive pulmonary disease exacerbations in the COPDGene Study: associated radiologic phenotypes. Radiology 2011; 261:274-282. PMID: 21788524; PMCID: PMC3184233.
http://radiology.rsna.org/content/261/1/274.full.pdf+html.
Abstract: http://radiology.rsna.org/content/261/1/274.abstract.
23. Castaldi P, Cho M, Litonjua A, Bakke P, Gulsvik A, Lomas D, Anderson W, Beaty T, Hokanson J, Crapo J, Laird N, Silverman E, the COPDGene and Eclipse Investigators. The association of genome-wide significant spirometric loci with COPD susceptibility. Am J Respir Cell Mol Biol 2011; 45:1147-1153. PMID: 21659657.
http://ajrcmb.atsjournals.org/content/45/6/1147.full.pdf+html.
Abstract: http://ajrcmb.atsjournals.org/content/45/6/1147.abstract.
24. Siedlinsk M, Cho M, Bakke P, Gulsvik A, Lomas D, Anderson W, Kong X, Rennard S, Terri Beaty, Hokanson J, Crapo J, Silverman E, the COPDGene and ECLIPSE Investigators Genome-wide association study of smoking behaviours in COPDGene patients. Thorax 2011; 66:894-902. PMID: 21685187.
http://thorax.bmj.com/content/66/10/894.full.pdf+html.
Abstract: http://thorax.bmj.com/content/66/10/894.abstract.
25. Young R, Hopkins R, Gamble G, Etzel C, El-Zein R, Crapo J. Genetic evidence linking lung cancer and COPD: a new perspective. The Application of Clinical Genetics 2011; 4:99-111.
http://www.dovepress.com/getfile.php?fileID=10561.
26. Qui W, Cho MH, Riley JH, Anderson WH, Singh D, Bakke P, Gulsvik A, Litonjua A, Lomas D, Crapo J, Beaty T, Celli B, Rennard S, Tal-Singer R, Fox S, Silverman E, Hersh C. Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLOS One 2011; 6(9):e24395. PMCID: PMC3174957.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174957/pdf/pone.0024395.pdf.
Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174957/?report=abstract.
27. Rambod M, Porszasz J, Make B, Crapo J, Casaburi R and the COPDGene Investigators. Six minute walk distance predictors, including computed tomography measures, in the COPDGene cohort. Chest 2011; Sep 29. [Epub ahead of print]. PMID: 21960696.
http://chestjournal.chestpubs.org/content/early/2011/09/28/chest.11-0870.full.pdf.
Abstract: http://chestjournal.chestpubs.org/content/early/2011/09/28/chest.11-0870.abstract.
28. Hardin M, Silverman E, Barr RG, Hansel N, Schroeder J, Make B, Crapo J, Hersh C and the COPDGene Investigators. The clinical features of the overlap between COPD and asthma. Respiratory Research 2011; 12:127. PMID: 21951550. PMCID: PMC3204243.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204243/pdf/1465-9921-12-127.pdf.
Abstract: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204243/?report=abstract.
29. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, Demeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, Macnee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK; on behalf of the ICGN, ECLIPSE, and COPDGene Investigators. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet 2012; 21(4):947-957. PMID: 22080838
Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22080838
30. Diaz AA, Come CE, Ross JC, Estepar RS, Han MK, Loring SH, Silverman EK, Washko G, and the COPDGene Investigators. Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT in subjects with COPD. Chest 2011; (epub Sept 22, 2011). PMID: 21940776.
http://chestjournal.chestpubs.org/content/early/2011/09/21/chest.11-1026.full.pdf.
Abstract: http://chestjournal.chestpubs.org/content/early/2011/09/21/chest.11-1026.abstract.
31. Swift I, Satti A, Kim V, Make B, Newell J, Steiner R, Wilson C, Murphy J, Silverman E, Criner G and the COPDGene Investigators. Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids. COPD 2012; 9(1): in press for February 2012.
32. Lynch DA, Murphy JR, Crapo JD, et al. A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD 2012; 9(2): in press for April 2012.
33. Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ.. Genetic association between human chitinases and lung function in COPD. Hum Genet 2011; Dec 28. [Epub ahead of print]. PMID: 22200767
34. Xu FJ, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, San Jose Estépar R, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AMK, Hunninghake GM, and the COPDGene Investigators. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 2012; in press. [Epub ahead of print]. PMID: 22246178.
http://ajrccm.atsjournals.org/content/early/2012/01/11/rccm.201108-1574OC.full.pdf.
http://ajrccm.atsjournals.org/content/early/2012/01/11/rccm.201108-1574OC.abstract.