Publications
Publications Resulting from the COPDGene Project
A downloadable pdf listing is at the bottom of this page.
1. Pillai SG, Ge D, Zhu G, Kong X, Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A, Ruppert A, Lodrup Carlsen KC, Roses A, Anderson W, Rennard SI, Lomas DA, Silverman EK, Goldstein DB, ICGN Investigators. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009 Mar; 5:e1000421. PMID: 19300482, PMC2650282. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650282
2. Washko GR, Dransfield MT, Estepar RS, Diaz A, Matsuoka S, Yamashiro T, Hatabu H, Silverman EK, Bailey WC, Reilly JJ. Airway wall attenuation: A biomarker of airway disease in subjects with COPD. J Appl Physiol Jul 2009; 107:185-191. PMID: 19407254, PMC2711787. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711787
3. Oberley-Deegan RE, Regan EA, Kinnula VL, Crapo JD. Extracellular superoxide dismutase and risk of COPD. COPD 2009 Aug; 6:307-312. PMID: 19811392, PMC4075061.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075061
4. Kindlmann GL, San Jose Estepar R, Smith SM, Westin CF. Sampling and visualizing creases with scale-space particles. IEEE Trans Vis Comput Graph 2009 Nov-Dec; 15:1415-1424. PMID: 19834216, PMC2891996. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891996/
5. Ross JC, San José Estépar R, Diaz A, Westin CF, Kikinis Ron, Silverman EK, Washko GR. Lung extraction, lobe segmentation and hierarchical region assessment for quantitative analysis on high resolution computed tomography images. Med Image Comput Comput Assist Interv 2009; 12(Pt 2):690-698. PMID: 20426172, PMC3061233. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061233/
6. Washko GR, Lynch DA, Matsuoka S, Ross JC, Umeoka S, Diaz A, Sciurba FC, Hunninghake GM, San José Estépar R, Silverman EK, Rosas IO, Hatabu H. Identification of early interstitial lung disease in smokers from the COPDGene study. Acad Radiol 2010; 17:48-53. PMID: 19781963, PMC2790552. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790552/
7. Regan EA, Hokanson JE, Murphy JR, Make B, Lynch DA, Beaty TH, Curran-Everett D, Silverman EK, Crapo JD. Genetic epidemiology of COPD (COPDGene) study design. COPD 2010; 7:32-43. PMID: 20214461, PMC2924193. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924193/
8. Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, Won S, Murphy JR, Beaty TH, Regan EA, Make BJ, Hokanson JE, Crapo JD, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Bakke P, Gulsvik A, Pillai SG, Silverman EK. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet 2010; 42:200-202. PMID: 20173748, PMC2828499. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828499/
9. Crapo JD. Preclinical vascular disease identifies smokers at risk for COPD. Proc Natl Acad Sci USA 2010 May; 107:8503-8504. PMID: 20442330, PMC2889364. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889364/
10. Washko GR. Diagnostic imaging in COPD. Semin Respir Crit Care Med 2010 Jun; 31:276-285. PMID: 20496297, PMC4334134. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334134/
11. Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci USA 2010 Aug; 107:15571-15576. PMID: 20713693, PMC2932580.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932580/
12. Murphy A, Won S, Rogers A, Chu HW, Raby BA, Lange C. On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples. Genet Epidemiol 2010 Sep; 34:582-590. PMID: 20718041, PMC3349936. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349936/
13. Diaz AA, Valim C, Yamashiro T, Estépar RS, Ross JC, Matsuoka S, Bartholmai B, Hatabu H, Silverman EK, Washko GR. Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers. Chest 2010; 138:880-887. PMID: 20558554, PMC2951760. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951760
14. Ross JC, San José Estépar R, Kindlmann G, Díaz A, Westin CF, Silverman EK, Washko GR. Automatic lung lobe segmentation using particles, thin plate splines, and maximum a posteriori estimation. Med Image Comput Assist Interv 2010; 13(Pt3):163-171. PMID: 20879396, PMC3049444. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049444/
15. Matsuoka S, Yamashiro T, Diaz A, San Jose Estepar R, Ross JC, Silverman EK, Kobayashi Y, Dransfield MT, Bartholmai BJ, Hatabu H, Washko GR. The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease: quantitative CT analysis. Acad Radiol 2011 Jan; 18:40-46. PMID: 20947389, PMC3006041. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006041/
16. Kim WJ, Hoffman E, Reilly J, Hersh C, DeMeo D, Washko G, Silverman, EK. Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD. Eur Respir J 2011 Jan; 37:39-43. PMID: 20525719, PMC3074301. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074301/
17. Yip WK, Lange C. Quantitative trait prediction based on genetic marker-array data: A simulation study. Bioinformatics 2011; 27:745-748. PMID: 21285022, PMC3105484. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105484
18. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO; COPDGene Investigators. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med 2011; 364:897-906. PMID: 21388308, PMC3074462. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074462/
19. Budoff MJ, Nasir K, Kinney GL, Hokanson JE, Barr RG, Steiner R, Nath H, Lopez-Garcia C, Black-Shinn J, Casaburi R. Coronary artery and thoracic calcium on noncontrast thoracic CT scans: Comparison of ungated and gated examinations in patients from the COPDGene cohort. J Cardiovasc Comput Tomogr 2011; 5:113-118. PMID: 21167806, PMC3075464. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075464/
20. Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK and the COPDGene Investigators. Clinical and radiographic predictors of GOLD-unclassified smokers in COPDGene. Am J Respir Crit Care Med 2011; 184:57-63. PMID: 21493737, PMC3172890. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172890
21. Lipman PJ, Cho MH, Bakke P, Gulsvik A, Kong X, Lomas DA, Anderson W, Silverman EK, Lange C. On the follow-up of genome-wide association studies: an overall test for the most promising SNPs. Genet Epidemiol 2011; 35:303-309. PMID: 21374717, PMC4096304. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096304
22. Wan ES, Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Won S, Lange C, Pillai SG, Anderson WH, Kong X, Lomas DA, Bakke PS, Gulsvik A, Regan EA, Murphy JR, Make BJ, Crapo JD, Wouters EF, Celli BR, Silverman EK, DeMeo DL; Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate End-Points (ECLIPSE); Norway-Bergen cohort; National Emphysema Treatment Trial; COPD Gene investigators. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2011; 45:304-310. PMID: 21037115, PMC3266061. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266061/
23. Foreman MG, Zhang L, Murphy J, Hansel NN, Make B, Hokanson JE, Washko G, Regan EA, Crapo JD, Silverman EK, DeMeo DL; the COPDGene Investigators. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene study. Am J Respir Crit Care Med 2011; 184:414-420. PMID: 21562134, PMC3175544. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175544
24. Hersh CP, Hokanson JE, Lynch DA, Washko GR, Make BJ, Crapo JD, Silverman EK, COPDGene Investigators. Family history is a risk factor for COPD. Chest 2011; 140:343-350. PMID: 21310839, PMC3198493. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198493
25. Kim YI, Schroeder J, Lynch D, Newell J, Make B, Friedlander A, Estépar RS, Hanania NA, Washko G, Murphy JR, Wilson C, Hokanson JE, Zach J, Butterfield K, Bowler RP, COPDGene Investigators. Gender differences of airway dimensions in anatomically matched sites on CT in smokers. COPD 2011; 8:285-292. PMID: 21756032, PMC3703311. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703311
26. Kim DK, Jacobson FL, Washko GR, Casaburi R, Make BJ, Crapo JD, Silverman EK, Hersh CP. Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study. Respir Med 2011; 105:1211-1221. PMID: 21396809, PMC3116986. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116986
27. Kim V, Han MK, Vance GB, Make BJ, Newell JD, Hokanson JE, Hersh CP, Stinson D, Silverman EK, Criner GJ, COPDGene Investigators. The chronic bronchitic phenotype of COPD: an analysis of the COPDGene study. Chest 2011; 140:626-633. PMID: 21474571, PMC3168856. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3168856
28. Han MK, Kazerooni EA, Lynch DA, Liu LX, Murray S, Curtis JL, Criner GJ, Kim V, Bowler RP, Hanania NA, Anzueto AR, Make BJ, Hokanson JE, Crapo JD, Silverman EK, Martinez FJ, Washko GR, COPDGene Investigators. Chronic obstructive pulmonary disease exacerbations in the COPDGene Study: associated radiologic phenotypes. Radiology 2011; 261:274-282. PMID: 21788524, PMC3184233. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184233
29. Siedlinski M, Cho MH, Bakke P, Gulsvik A, Lomas DA, Anderson W, Kong X, Rennard SI, Beaty TH, Hokanson JE, Crapo JD, Silverman EK; COPDGene Investigators; ECLIPSE Investigators. Genome-wide association study of smoking behaviors in patients with COPD. Thorax 2011; 66:894-902. PMID: 21685187, PMC3302576. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302576
30. Castaldi PJ, DeMeo DL, Hersh CP, Lomas DA, Soerheim IC, Gulsvik A, Bakke P, Rennard S, Pare P, Vestbo J, AATGM Investigators, ICGN Investigators, Silverman EK. The impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax 2011 Oct; 66:903-909. PMID: 21163806, PMC3312798. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312798/
31. Han MK, Curran-Everett D, Dransfield MT, Criner GJ, Zhang L, Murphy JR, Hansel NN, DeMeo DL, Hanania NA, Regan EA, Make BJ, Martinez FJ, Westney GE, Foreman MG; COPDGene Investigators. Racial differences in quality of life with COPD. Chest 2011; 140:1169-1176. PMID: 21636665, PMC3205846. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205846
32. Castaldi PJ, Cho MH, Litonjua AA, Bakke P, Gulsvik A, Lomas DA, Anderson W, Beaty TH, Hokanson JE, Crapo JD, Laird N, Silverman EK; COPDGene and ECLIPSE Investigators. The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol 2011; 45:1147-1153. PMID: 21659657, PMC3262664. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262664
33. Risholm P, Ross J, Washko GR, Wells WM. Probabilistic elastography: estimating lung elasticity. Inf Process Med Imaging 2011; 22:699-710. PMID: 21761697, PMC3249413. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249413
34. Young RP, Hopkins RJ, Gamble GD, Etzel C, El-Zein R, Crapo JD. Genetic evidence linking lung cancer and COPD: a new perspective. Appl Clin Genet 2011; 4:99-111. PMID: 23776371, PMC3681182. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681182
35. Qiu W, Cho MH, Riley JH, Anderson WH, Singh D, Bakke P, Gulsvik A, Litonjua AA, Lomas DA, Crapo JD, Beaty TH, Celli BR, Rennard S, Tal-Singer R, Fox SM, Silverman EK, Hersh CP; and the ECLIPSE Investigators. Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One 2011; 6(9):e24395. PMID: 21949713, PMC3174957. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174957
36. Kim DK, Hersh CP, Washko GR, Hokanson JE, Lynch DA, Newell JD, Murphy JR, Crapo JD, Silverman EK; COPD Gene Investigators. Epidemiology, radiology, and genetics of nicotine dependence in COPD. Respir Res 2011; 12:9. PMID: 21232152, PMC3033825. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033825
37. Hardin M, Silverman EK, Barr RG, Hansel NN, Schroeder JD, Make BJ, Crapo JD, Hersh CP; the COPDGene Investigators. The clinical features of the overlap between COPD and asthma. Respir Res 2011; 12:127. PMID: 21951550, PMC3204243. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204243
38. Swift I, Satti A, Kim V, Make BJ, Newell J, Steiner RM, Wilson C, Murphy JR, Silverman EK, Criner GJ; COPDGene Investigators. Demographic, physiologic and radiographic characteristics of COPD patients taking chronic systemic corticosteroids. COPD 2012 Feb; 9:29-35. PMID: 22292596, PMC3764986. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764986
39. Cho MH, Castaldi PJ, Wan ES, Siedlinski M, Hersh CP, DeMeo DL, Himes BE, Sylvia JS, Klanderman BJ, Ziniti JP, Lange C, Litonjua AA, Sparrow D, Regan EA, Make BJ, Hokanson JE, Murray T, Hetmanski JB, Pillai SG, Kong X, Anderson WH, Tal-Singer R, Lomas DA, Coxson HO, Edwards LD, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Gulsvik A, Crapo JD, Beaty TH, Silverman EK; on behalf of the ICGN, ECLIPSE, and COPDGene Investigators. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet 2012 Feb; 21:947-957. PMID: 22080838, PMC3298111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298111
40. Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, San Jose Estépar R, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM, the COPDGene Investigators. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med 2012 Mar; 185:547-556. PMID: 22246178, PMC3297101. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297101
41. Diaz AA, Come CE, Ross JC, San José Estépar R, Han MK, Loring SH, Silverman EK, Washko GR; COPDGene Investigators. Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest 2012 Mar; 141:736-744. PMID: 21940776, PMC3296457. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296457
42. Doyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H. Kosas IO, Hunninghake GM, COPDGene Investigators. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med 2012 Apr; 185:756-762. PMID: 22268134, PMC3326424. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326424
43. Christoforou A, Dondrup Michael, Mattingsdal M, Mattheisen M, Giddaluru S, Nothen MM, Rietschel M, Cichon S, Djurovic S, Andreassen IA, Jonassen I, Steen VM, Puntervoll P, Le Hellard S. Linkage-disequilibrium-based binning affects the interpretation of GWASs. Am J Hum Genet 2012 Apr; 90:727-733. PMID: 22444669, PMC3322240. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322240
44. Rambod M, Porszasz J, Make BJ, Crapo JD, Casaburi R; the COPDGene Investigators. Six-minute walk distance predictors, including CT scan measures, in the COPDGene Cohort. Chest 2012 Apr; 141:867-875. PMID: 21960696, PMC3318949. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318949
45. COPDGene CT Workshop Group, Barr RG, Berkowitz EA, Bigazzi F, Bode F, Bon J, Bowler RP, Chiles C, Crapo JD, Criner GJ, Curtis JL, Dass C, Dirksen A, Dransfield MT, Edula G, Erikkson L, Friedlander A, Galperin-Aizenberg M, Gefter WB, Gierada DS, Grenier PA, Goldin J, Han MK, Hanania NA, Hansel NN, Jacobson FL, Kauczor HU, Kinnula VL, Lipson DA, Lynch DA, MacNee W, Make BJ, Mamary AJ, Mann H, Marchetti N, Mascalchi M, McLennan G, Murphy JR, Naidich D, Nath H, Newell JD Jr, Pistolesi M, Regan EA, Reilly JJ, Sandhaus R, Schroeder JD, Sciurba F, Shaker S, Sharafkhaneh A, Silverman EK, Steiner RM, Strange C, Sverzellati N, Tashjian JH, Beek EJ, Washington L, Washko GR, Westney G, Wood SA, Woodruff PG. A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation. COPD 2012 Apr; 9:151-159. PMID: 22429093, PMC3752926. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752926
46. Martinez CH, Chen YH, Westgate PM, Liu LX, Murray S, Curtis JL, Make BJ, Kazerooni EA, Lynch DA, Marchetti N, Washko GR, Martinez FJ, Han MK; COPDGene Investigators. Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax 2012 May; 67:399-406. PMID: 22514236, PMC3719874. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719874
47. Adhikari K, AlChawa T, Ludwig K, Mangold E, Laird N, Lange C. Is it rare or common? Genet Epidemiol 2012 Jul; 36:419-429. PMID: 22549767, PMC3641852. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641852
48. Aminuddin F, Akhabir L, Stefanowicz D, Paré PD, Connett JE, Anthonisen NR, Fahy JV, Seibold MA, Burchard EG, Eng C, Gulsvik A, Bakke P, Cho MH, Litonjua A, Lomas DA, Anderson WH, Beaty TH, Crapo JD, Silverman EK, Sandford AJ. Genetic association between human chitinases and lung function in COPD. Hum Genet 2012 Jul; 131:1105-1114. PMID: 22200767, PMC3771523. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771523
49. Stewart JI, Moyle S, Criner GJ, Wilson C, Tanner R, Bowler RP, Crapo JD, Zeldin RK, Make BJ, Regan EA, for the COPDGene Investigators. Automated telecommunication to obtain longitudinal follow-up in a multicenter cross-sectional COPD study. COPD 2012 Aug; 9:466-472. PMID: 22676387, PMC3698488. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698488
50. Sieren JP, Newell JD, Judy PF, Lynch DA, Chan KS, Guo J, Hoffman EA. Reference standard and statistical model for intersite and temporal comparisons of CT attenuation in a multicenter quantitative lung study. Med Phys 2012 Sep; 39:5757-5767. PMID: 22957640, PMC3448623. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448623
51. Wells JM, Washko GR, Han MK, Abbas N, Nath H, Mamary AJ, Regan E, Bailey WC, Martinez FJ, Westfall E, Beaty TH, Curran-Everett D, Curtis JL, Hokanson JE, Lynch DA, Make BJ, Crapo JD, Silverman EK, Bowler RP, Dransfield MT; COPDGene Investigators; ECLIPSE Study Investigators. Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med 2012 Sep; 367:913-921. PMID: 22938715, PMC 3690810. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690810
52. Wilk JB, Shrine NR, Loehr LR, Zhao JH, Manichaikul A, Lopez LM, Smith AV, Heckbert SR, Smolonska J, Tang W, Loth DW, Curjuric I, Hui J, Cho MH, Latourelle JC, Henry AP, Aldrich M, Bakke P, Beaty TH, Bentley AR, Borecki IB, Brusselle GG, Burkart KM, Chen TH, Couper D, Crapo JD, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock DB, Harris TB, Hofman A, Imboden M, James AL, Khaw KT, Lahousse L, Launer LJ, Litonjua A, Liu Y, Lohman KK, Lomas DA, Lumley T, Marciante KD, McArdle WL, Meibohm B, Morrison AC, Musk AW, Myers RH, North KE, Postma DS, Psaty BM, Rich SS, Rivadeneira F, Rochat T, Rotter JI, Soler Artigas M, Starr JM, Uitterlinden AG, Wareham NJ, Wijmenga C, Zanen P, Province MA, Silverman EK, Deary IJ, Palmer LJ, Cassano PA, Gudnason V, Barr RG, Loos RJ, Strachan DP, London SJ, Boezen HM, Probst-Hensch N, Gharib SA, Hall IP, O'Connor GT, Tobin MD, Stricker BH. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med 2012 Oct; 186:622-632. PMID: 22837378, PMC3480517. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480517
53. Ginsburg SB, Lynch DA, Bowler RP, Schroeder JD. Automated texture-based quantification of centrilobular nodularity and centrilobular emphysema in chest CT images. Acad Radiol 2012 Oct; 19:1241-1251. PMID: 22958719, PMC3679917. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679917
54. Zach JA, Newell JD Jr, Schroeder J, Murphy JR, Curran-Everett D, Hoffman EA, Westgate PM, Han MK, Silverman EK, Crapo JD, Lynch DA, COPDGene Investigators. Quantitative CT of the lungs and airways in healthy non-smoking adults. Invest Radiol 2012 Oct; 47:596-602. PMID: 22836310, PMC3703944. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703944
55. Galbán CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galbán S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD. CT-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med 2012 Nov; 18:1711-1715. PMID: 23042237, PMC3493851. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493851
56. Kim DK, Cho MH, Hersh CP, Lomas DA, Miller BE, Kong X, Bakke P, Gulsvik A, Agusti A, Wouters E, Celli B, Coxson H, Vestbo J, MacNee W, Yates JC, Rennard S, Litonjua A, Qiu W, Beaty TH, Crapo JD, Riley JH, Tal-Singer R, Silverman EK; on behalf of the ECLIPSE, ICGN, and COPDGene Investigators. Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012 Dec; 186:1238-1247. PMID: 23144326, PMC3622441. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622441
57. Fier H, Won S, Prokopenko D, AlChawa T, Ludwig KU, Fimmers R, Silverman EK, Pagano M, Mangold E, Lange C. 'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics 2012 Dec; 28:3027-3033. PMID: 23044548, PMC3516147. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516147
58. Qiao D, Yip WK, Lange C. Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data. BMC Bioinformatics 2012; 13:100. PMID: 22591016, PMC3434015. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434015
59. Mendoza CS, Washko GR, Ross JC, Díaz AA, Lynch DA, Crapo JD, Silverman EK, Begoña A, Serrano-Gotarredona C, Estépar RS. Emphysema quantification in a multi-scanner HRCT cohort using local intensity distributions. In: 2012 9th IEEE International Symposium on Biomedical Imaging. Institute of Electrical and Electronics Engineers. Proc IEEE Int Symp Biomed Imaging 2012; 2012:474-477. PMC3670097. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670097
60. Estépar RS, Ross JC, Kindlmann GL, Díaz A, Okajima Y, Kikinis R, Westin CR, Silverman EK, Washko GR. Automatic airway analysis for genome-wide association studies in COPD. In: 2012 9th IEEE International Symposium on Biomedical Imaging. Institute of Electrical and Electronics Engineers. Proc IEEE Int Symp Biomed Imaging 2012; 2012:1467-1470. PMC3670103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670103
61. Estépar RS, Ross JC, Krissian K, Schultz T, Washko GR, Kindlmann G. Computational vascular morphometry for the assessment of pulmonary vascular disease based on scale-space particles. In: 2012 9th IEEE International Symposium on Biomedical Imaging. Institute of Electrical and Electronics Engineers. Proc IEEE Int Symp Biomed Imaging. 2012; pp 1479-1482. PMC3670102. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670102
62. Kurugol S, San Jose Estepar R, Ross J, Washko GR. Aorta segmentation with a 3D level set approach and quantification of aortic calcifications in non-contrast chest CT. Conf Proc IEEE Eng Med Biol Soc 2012; 2012:2343-2346. PMID: 23366394, PMC3671590. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671590
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